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WHAT IS MULTIPLE MYELOMA?
SIGNS & SYMPTOMS OF MULTIPLE MYELOMA
HOW IS MULTIPLE MYELOMA DIAGNOSED?
TYPES OF MULTIPLE MYELOMA
July 6, 2018
Myeloma genetics is an important piece of the myeloma puzzle. If we know what type of myeloma we have, we can see if there are patterns of treatments received and resulting outcomes. The most commonly run genetics test is called the FISH test. A fluorescence in situ hybridization test (FISH) maps out the genetic material of a cell. It uses special fluorescent dyes that only attach to specific parts of chromosomes. FISH can find most chromosome changes (such as deletions or transloca[...]
January 11, 2018
The story of Immunomodulatory drugs for the treatment of multiple myeloma is one of serendipity. The immunomodulatory drug thalidomide was used in the 1950s to treat morning sickness but was discontinued in the early 1960s after it was found to cause birth defects. Dr. Ira Wolmer, a cardiologist had relapsed myeloma. His wife had heard of angiogenesis work performed by Dr. Judah Folkman and in 1999 asked her husband's doctor, Dr. Bart Barlogie, to use thalidomide for her husband.[...]
July 22, 2017
Many myeloma clinical trials include approval criteria based on the number of "lines" of therapy a patient has already received. For example, daratumumab is now approved for patients who have received one prior line of therapy. Other clinical trials require a patient to have over three lines of therapy or more.But with myeloma therapy typically given in combinations, what does a "line" include? It was confusing enough for myeloma experts Vincent Rajkumar, MD (Mayo Clinic), Paul Richa[...]
June 29, 2017
Smoldering myeloma is a precursor stage of multiple myeloma. Historically, smoldering myeloma patients have not been put on active treatment because many of them only have a 10% risk per year for the first 5 years of progressing to active myeloma (with a cumulative 50% risk). Until treatment side effects become completely benign, it is critical for doctors to assess the likelihood of progression to know who will and won't progress in order to treat those who need it most. One[...]