• Myeloma Clinical Trials
    • Mar 08, 2018

    Clinical Trial: Seattle Genetics’ SGN-CD48A Phase I Study for Patients with Relapsed/Refractory Myeloma

Seattle Genetics has just announced that the first patient has been dosed in a Phase I study for their new drug SGN-CD48A for patients with relapsed or refractory multiple myeloma. The Company’s antibody-drug conjugate (ADC) technology harnesses the targeting ability of antibodies to deliver cell-killing agents directly to cancer cells.
SGN-CD48A is a new drug that targets CD48, a cell surface protein that is highly expressed in multiple myeloma. The technology innovation enables conjugation (or linking together) of eight molecules of the microtubule-disrupting cytotoxic agent monomethyl auristatin E (MMAE) to a CD48-targeted monoclonal antibody. SGN-CD48A is designed to be highly stable in circulation and release an increased amount of MMAE upon internalization into CD48-expressing cells, producing greater and demonstrated promising anti-tumor activity in preclinical studies.
This new compound will be administered as a ‘single agent’ in the study (as opposed to the doublets, triplets or even quadruplets that are typical). The Phase 1 study is a multicenter open-label dose-escalation trial designed to enroll approximately 75 patients with relapsed or refractory myeloma. SGN-CD48A will be administered at an initial dosing interval of every three weeks. In going through the details of the inclusion/exclusion criteria for this clinical study it is noted that the Company is specifically looking for :

Patients must not have other therapeutic options known to provide clinical benefit in multiple myeloma available to them. Prior lines of therapy must include at least a proteasome inhibitor, an immunomodulatory drug, and an anti-CD38 antibody.’

In other words, if as a patient you have relapsed after treatment with products such as Revlimid, Pomalyst or Thalomid (immunomodulators) AND Velcade, Ninlaro or Kyprolis (proteasome inhibitors) AND Darzalex (anti-CD38 antibody), then this may become an alternative for you.
This study is open at the Yale Cancer Center in Connecticut.
To learn more, find this study on SparkCures here:
Seattle Genetics Myeloma Study CD48A  
Seattle Genetics Myeloma Study CD352A  

About Author

Paul Kleutghen

I've been a primary Plasma Cell Leukemia patient since January 2014. My wife, Vicki, and I have two adult kids and one grandson (the light of our lives). The PCL hasn’t stopped us from doing what we love the most : travel, albeit with some extra precautions these days. I've had a +20 year career in various aspects of the pharma industry and am a retired President/CEO of a generic pharmaceutical company. This photo is hanging on the “Survivor Wall” of the Duke Bone Marrow Transplant Center with the proverbial MM “ monkey on my back”.

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